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Do Human Beings Carry Expiration Dates?

On June 9, the Wall Street Journal carried the following story under the heading Mind & Matter written by Matt Ridley.

After celebrating her 60th year on the throne in style this past week, Britain’s Queen Elizabeth II can now look forward to breaking some more records. She is already, at 86, Britain’s oldest monarch (were she to die now, her son would be the 12th oldest). On Sept 10 2015, she would pass Queen Victoria to become the longest-reigning monarch in British history. To beat Louis XIV (who succeeded to the throne at the age of 4) for the longest reign in European history, she would have to live to 98.

Elizabeth II is still going strong, but the maximum human lifespan isn’t rising at anything like the rate of average life expectancy, which is rushing upward globally at the rate of about three months a year, mainly because of progress against premature mortality. Indeed, we may already have hit some kind of limit for maximum lifespan—perhaps because natural selection, with its strict focus on reproductive success, has no particular need to preserve genes that would keep us going to 150.

The oldest woman in  the world, Besse Cooper, a retired schoolteacher in Georgia will be 116 on Aug. 26, according to the Geronotology Research Group, an organization that studies aging issues. That’s a great age but it’s a hefty six years short of the record: 122 years and 64 days, set by Jeanne Calment of France in 1997. In other words, if Mrs. Cooper can get there, Mrs. Calment’s record will have stood for 21 years; if she can’t, maybe longer.  That’s a long time considering that there are now nearly a half million centenarians alive in the world. That number has been going up 7% a year but the number of those over 115 is not increasing.

If Mrs. Cooper does not take the record, there are only two other 115-year olds alive to take on the challenge,and one of them is a man: Jiroemon Kimura, a retired postman from Kyoto. He’s within seven months of beating the age record for his sex, set by Christian Mortensen, who died in 1998. But Mr. Kimura is less likely than a woman to make 122, and there are fewer women over 115 today (two) than there were in 2006 (four) or even 1997 (three).

At least two people died after their 110th birthdays in the 1800s, if you’re willing to trust the birth certificates. So the increase of 12 years in maximum life expectancy during the 20th century was just one-third as large as the increase in average life expectancy during the period (36 years).

In 2002, James Vaupal of the Max Planck Institute for Demographic Research in Rostock, Germany, startled demographers by pointing out that every estimate published of the level at which average life expectancy would level out has been broken within a few years. Jay Olshansky of the University of Illionis, however argues that since 1980 this has no longer been true for already-old people in rich countries like the U.S.: Official estimates of remaining years of life for a woman aged 65 should be revised downward.

Thanks to healthier lifestyles, more and more people are surviving into old age. But that is not incompatible with there being a sort of expiration date on human lifespan. Most scientists think the decay of the body by aging is not itself programmed by genes, but the repair mechanisms that delay decay are.

In human beings, genes that help keep you alive as a parent or even grandparent have had a selective advantage through helping children thrive, but ones that keep you alive as a great-grandparent–who likely doesn’t play much of a role in the well-being and survival of great-grand children–have probably never contributed to reproductive success.

In other words, there is perhaps no limit to the number of people who can reach 90 or 100, but getting past 120 may never be possible, and 150 is probably unattainable, absent generic engineering–even for a monarch.

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